4OFB

Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor

4OFB の概要

• エントリーDOI: 10.2210/pdb4ofb/pdb
• 分子名称: Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor (2 entities in total)
• 機能のキーワード: brct domain, dsb dna damage repair, non-phosphorylated peptide, protein binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26185.02

構造登録者

Sun, L.,Edwards, R.A.,Glover, J.N.M. (登録日: 2014-01-14, 公開日: 2015-04-15, 最終更新日: 2017-11-22)

• 主引用文献: White, E.R.,Sun, L.,Ma, Z.,Beckta, J.M.,Danzig, B.A.,Hacker, D.E.,Huie, M.,Williams, D.C.,Edwards, R.A.,Valerie, K.,Glover, J.N.,Hartman, M.C.; Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.; Acs Chem.Biol., 10:1198-1208, 2015; PubMed: 25654734; DOI: 10.1021/cb500757u

実験手法

X-RAY DIFFRACTION (3.05 Å)