Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex

Summary for 4OEE

Related4OEF 4OEG
DescriptorFibroblast growth factor 2, 2-deoxy-3-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, methyl 2-O-sulfo-alpha-L-idopyranosiduronic acid, ... (4 entities in total)
Functional Keywordsheparin/heparin sulfate binding, protein binding
Biological sourceHomo sapiens (human)
Cellular locationSecreted P09038
Total number of polymer chains1
Total molecular weight17877.26
Li, Y.C.,Hsiao, C.D. (deposition date: 2014-01-13, release date: 2014-07-09, Last modification date: 2018-04-04)
Primary citation
Li, Y.C.,Ho, I.H.,Ku, C.C.,Zhong, Y.Q.,Hu, Y.P.,Chen, Z.G.,Chen, C.Y.,Lin, W.C.,Zulueta, M.M.,Hung, S.C.,Lin, M.G.,Wang, C.C.,Hsiao, C.D.
Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9:1712-1717, 2014
PubMed: 24959968 (PDB entries with the same primary citation)
DOI: 10.1021/cb500298q
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.186302.6%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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