4OBQ

MAP4K4 in complex with inhibitor (compound 31), N-[3-(4-AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE

Summary for 4OBQ

• Entry DOI: 10.2210/pdb4obq/pdb
• Related: 4OBO 4OBP
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O95819
• Total number of polymer chains: 2
• Total formula weight: 76325.10

Authors

Harris, S.F.,Wu, P.,Coons, M. (deposition date: 2014-01-07, release date: 2014-04-23, Last modification date: 2024-02-28)

• Primary citation: Crawford, T.D.,Ndubaku, C.O.,Chen, H.,Boggs, J.W.,Bravo, B.J.,Delatorre, K.,Giannetti, A.M.,Gould, S.E.,Harris, S.F.,Magnuson, S.R.,McNamara, E.,Murray, L.J.,Nonomiya, J.,Sambrone, A.,Schmidt, S.,Smyczek, T.,Stanley, M.,Vitorino, P.,Wang, L.,West, K.,Wu, P.,Ye, W.; Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization.; J.Med.Chem., 57:3484-3493, 2014; PubMed: 24673130; DOI: 10.1021/jm500155b

Experimental method

X-RAY DIFFRACTION (2.19 Å)