4OBO

MAP4K4 in complex with inhibitor (compound 22), 6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE

Summary for 4OBO

Entry DOI	10.2210/pdb4obo/pdb
Related	4OBP 4OBQ
Descriptor	Mitogen-activated protein kinase kinase kinase kinase 4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ... (5 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : O95819
Total number of polymer chains	2
Total formula weight	76237.07
Authors	Harris, S.F.,Wu, P.,Coons, M. (deposition date: 2014-01-07, release date: 2014-04-23, Last modification date: 2024-02-28)
Primary citation	Crawford, T.D.,Ndubaku, C.O.,Chen, H.,Boggs, J.W.,Bravo, B.J.,Delatorre, K.,Giannetti, A.M.,Gould, S.E.,Harris, S.F.,Magnuson, S.R.,McNamara, E.,Murray, L.J.,Nonomiya, J.,Sambrone, A.,Schmidt, S.,Smyczek, T.,Stanley, M.,Vitorino, P.,Wang, L.,West, K.,Wu, P.,Ye, W. Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization. J.Med.Chem., 57:3484-3493, 2014 Cited by PubMed: 24673130 DOI: 10.1021/jm500155b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation