4O74

Crystal structure of the first bromodomain of human BRD4 in complex with BI 2536

4O74 の概要

• エントリーDOI: 10.2210/pdb4o74/pdb
• 関連するPDBエントリー: 4O70 4O71 4O72 4O73 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F
• 分子名称: Bromodomain-containing protein 4, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31534.39

構造登録者

Ember, S.W.,Zhu, J.-Y.,Watts, C.,Schonbrunn, E. (登録日: 2013-12-24, 公開日: 2014-03-05, 最終更新日: 2023-09-20)

• 主引用文献: Ember, S.W.,Zhu, J.Y.,Olesen, S.H.,Martin, M.P.,Becker, A.,Berndt, N.,Georg, G.I.,Schonbrunn, E.; Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.; Acs Chem.Biol., 9:1160-1171, 2014; PubMed: 24568369; DOI: 10.1021/cb500072z

実験手法

X-RAY DIFFRACTION (1.45 Å)