4O4P

Structure of P450 BM3 A82F F87V in complex with S-omeprazol

Summary for 4O4P

• Entry DOI: 10.2210/pdb4o4p/pdb
• Related: 4KEY
• Descriptor: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, ... (4 entities in total)
• Functional Keywords: p450, monoxygenase, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Bacillus megaterium
• Cellular location: Cytoplasm (By similarity): P14779
• Total number of polymer chains: 2
• Total formula weight: 106286.84

Authors

Leys, D. (deposition date: 2013-12-19, release date: 2014-01-29, Last modification date: 2023-09-20)

• Primary citation: Butler, C.F.,Peet, C.,McLean, K.J.,Baynham, M.T.,Blankley, R.T.,Fisher, K.,Rigby, S.E.,Leys, D.,Voice, M.W.,Munro, A.W.; Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3.; Biochem.J., 460:247-259, 2014; PubMed: 24588219; DOI: 10.1042/BJ20140030

Experimental method

X-RAY DIFFRACTION (1.83 Å)