4NZ2

Crystal structure of CYP2C9 in complex with an inhibitor

Summary for 4NZ2

Entry DOI	10.2210/pdb4nz2/pdb
Related	4NY4
Descriptor	Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (6 entities in total)
Functional Keywords	cytochrome p-450, cyp2c9, inhibitor, structure-based drug design, drug metabolism, monooxygenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11712
Total number of polymer chains	2
Total formula weight	110919.84
Authors	Branden, G.,Sjogren, T.,Xue, Y. (deposition date: 2013-12-11, release date: 2014-08-13, Last modification date: 2024-02-28)
Primary citation	Branden, G.,Sjogren, T.,Schnecke, V.,Xue, Y. Structure-based ligand design to overcome CYP inhibition in drug discovery projects. Drug Discov Today, 19:905-911, 2014 Cited by PubMed: 24642031 DOI: 10.1016/j.drudis.2014.03.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation