4NXO

Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768

Summary for 4NXO

• Entry DOI: 10.2210/pdb4nxo/pdb
• Descriptor: Insulin-degrading enzyme, ZINC ION, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, ... (9 entities in total)
• Functional Keywords: hydrolase, inhibitor, cysteine free, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14735
• Total number of polymer chains: 2
• Total formula weight: 232179.28

Authors

Liang, W.G.,Deprez, R.,Deprez, B.,Tang, W. (deposition date: 2013-12-09, release date: 2015-10-07, Last modification date: 2023-09-20)

• Primary citation: Deprez-Poulain, R.,Hennuyer, N.,Bosc, D.,Liang, W.G.,Enee, E.,Marechal, X.,Charton, J.,Totobenazara, J.,Berte, G.,Jahklal, J.,Verdelet, T.,Dumont, J.,Dassonneville, S.,Woitrain, E.,Gauriot, M.,Paquet, C.,Duplan, I.,Hermant, P.,Cantrelle, F.X.,Sevin, E.,Culot, M.,Landry, V.,Herledan, A.,Piveteau, C.,Lippens, G.,Leroux, F.,Tang, W.J.,van Endert, P.,Staels, B.,Deprez, B.; Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.; Nat Commun, 6:8250-8250, 2015; PubMed: 26394692; DOI: 10.1038/ncomms9250

Experimental method

X-RAY DIFFRACTION (2.73 Å)