4NW5
Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8
Summary for 4NW5
Entry DOI | 10.2210/pdb4nw5/pdb |
Related | 4NW6 |
Descriptor | Ribosomal protein S6 kinase alpha-3, 7-(2-fluoro-6-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P51812 |
Total number of polymer chains | 1 |
Total formula weight | 37629.41 |
Authors | Appleton, B.A. (deposition date: 2013-12-05, release date: 2014-02-19, Last modification date: 2024-02-28) |
Primary citation | Costales, A.,Mathur, M.,Ramurthy, S.,Lan, J.,Subramanian, S.,Jain, R.,Atallah, G.,Setti, L.,Lindvall, M.,Appleton, B.A.,Ornelas, E.,Feucht, P.,Warne, B.,Doyle, L.,Basham, S.E.,Aronchik, I.,Jefferson, A.B.,Shafer, C.M. 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors. Bioorg.Med.Chem.Lett., 24:1592-1596, 2014 Cited by PubMed: 24534486DOI: 10.1016/j.bmcl.2014.01.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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