4NQC

Crystal structure of TCR-MR1 ternary complex and covalently bound 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil

4NQC の概要

• エントリーDOI: 10.2210/pdb4nqc/pdb
• 関連するPDBエントリー: 4GUP 4L4V 4LCW 4NQD 4NQE
• 分子名称: Major histocompatibility complex class I-related gene protein, Beta-2-microglobulin, TCR alpha chain, ... (7 entities in total)
• 機能のキーワード: mr1, t-cell receptor, immune receptor complex, ig-fold, protein binding, schiff base, membrane, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass membrane protein; Extracellular side. Isoform 4: Secreted. Isoform 3: Cell membrane ; Single-pass type I membrane protein : Q95460; Secreted : P61769
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 187996.51

構造登録者

Birkinshaw, R.W.,Rossjohn, J. (登録日: 2013-11-25, 公開日: 2014-04-16, 最終更新日: 2014-11-19)

• 主引用文献: Corbett, A.J.,Eckle, S.B.,Birkinshaw, R.W.,Liu, L.,Patel, O.,Mahony, J.,Chen, Z.,Reantragoon, R.,Meehan, B.,Cao, H.,Williamson, N.A.,Strugnell, R.A.,Van Sinderen, D.,Mak, J.Y.,Fairlie, D.P.,Kjer-Nielsen, L.,Rossjohn, J.,McCluskey, J.; T-cell activation by transitory neo-antigens derived from distinct microbial pathways.; Nature, 509:361-365, 2014; PubMed: 24695216; DOI: 10.1038/nature13160

実験手法

X-RAY DIFFRACTION (2.5 Å)