4NMM
Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor
Summary for 4NMM
Entry DOI | 10.2210/pdb4nmm/pdb |
Related | 4LDJ 4OBE |
Descriptor | GTPase KRas, MAGNESIUM ION, 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, ... (4 entities in total) |
Functional Keywords | small gtpase, gdp bound, oncogenic mutation, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side: P01116 |
Total number of polymer chains | 1 |
Total formula weight | 19927.51 |
Authors | Hunter, J.C.,Gurbani, D.,Lim, S.M.,Westover, K.D. (deposition date: 2013-11-15, release date: 2014-06-04, Last modification date: 2023-09-20) |
Primary citation | Hunter, J.C.,Gurbani, D.,Ficarro, S.B.,Carrasco, M.A.,Lim, S.M.,Choi, H.G.,Xie, T.,Marto, J.A.,Chen, Z.,Gray, N.S.,Westover, K.D. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111:8895-8900, 2014 Cited by PubMed: 24889603DOI: 10.1073/pnas.1404639111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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