4NJV
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with ritonavir
Summary for 4NJV
Entry DOI | 10.2210/pdb4njv/pdb |
Related | 4NJS 4NJT 4NJU |
Related PRD ID | PRD_001001 |
Descriptor | Protease, RITONAVIR (3 entities in total) |
Functional Keywords | multidrug-resistance, hiv-1 protease, ritonavir, rit, protease inhibitor, kaletra, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 4 |
Total formula weight | 45073.00 |
Authors | Yedidi, R.S.,Garimella, H.,Chang, S.B.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Mitsuya, H. (deposition date: 2013-11-11, release date: 2014-04-02, Last modification date: 2024-02-28) |
Primary citation | Yedidi, R.S.,Garimella, H.,Aoki, M.,Aoki-Ogata, H.,Desai, D.V.,Chang, S.B.,Davis, D.A.,Fyvie, W.S.,Kaufman, J.D.,Smith, D.W.,Das, D.,Wingfield, P.T.,Maeda, K.,Ghosh, A.K.,Mitsuya, H. A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58:3679-3688, 2014 Cited by PubMed: 24752271DOI: 10.1128/AAC.00107-14 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report