4NGS

Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor

4NGS の概要

• エントリーDOI: 10.2210/pdb4ngs/pdb
• 関連するPDBエントリー: 3D7H 4NGM 4NGN 4NGP 4NGQ 4NGR 4NGT
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: hydrolase, glutamate carboxypeptidase ii, psma, naaladase, urea-based inhibitor, caboxypeptidase, glycoprotein, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 87619.11

構造登録者

Tykvart, J.,Pachl, P. (登録日: 2013-11-02, 公開日: 2014-06-18, 最終更新日: 2020-07-29)

• 主引用文献: Tykvart, J.,Schimer, J.,Barinkova, J.,Pachl, P.,Postova-Slavetinska, L.,Majer, P.,Konvalinka, J.,Sacha, P.; Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.; Bioorg.Med.Chem., 22:4099-4108, 2014; PubMed: 24954515; DOI: 10.1016/j.bmc.2014.05.061

実験手法

X-RAY DIFFRACTION (1.68 Å)