4NGQ
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
4NGQ の概要
エントリーDOI | 10.2210/pdb4ngq/pdb |
関連するPDBエントリー | 3D7H 4NGM 4NGN 4NGP 4NGR 4NGS 4NGT |
分子名称 | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
機能のキーワード | hydrolase, metallopeptidase, glycoprotein, urea-based inhibitor, trasmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 87786.11 |
構造登録者 | |
主引用文献 | Tykvart, J.,Schimer, J.,Barinkova, J.,Pachl, P.,Postova-Slavetinska, L.,Majer, P.,Konvalinka, J.,Sacha, P. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg.Med.Chem., 22:4099-4108, 2014 Cited by PubMed: 24954515DOI: 10.1016/j.bmc.2014.05.061 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.08 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)