4N7B

Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate reductase from Plasmodium falciparum

4N7B の概要

• エントリーDOI: 10.2210/pdb4n7b/pdb
• 分子名称: LytB, FE3-S4 CLUSTER, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: iron-sulfur-cluster binding, oxidoreductase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64062.25

構造登録者

Rekittke, I.,Jomaa, H.,Ermler, U. (登録日: 2013-10-15, 公開日: 2013-11-20, 最終更新日: 2024-02-28)

主引用文献

Rekittke, I.,Olkhova, E.,Wiesner, J.,Demmer, U.,Warkentin, E.,Jomaa, H.,Ermler, U.
Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum.
Febs Lett., 587:3968-3972, 2013

PubMed Abstract: Terpenoid precursor biosynthesis occurs in human and many pathogenic organisms via the mevalonate and 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways, respectively. We determined the X-ray structure of the Fe/S containing (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase (LytB) of the pathogenic protozoa Plasmodium falciparum which catalyzes the terminal step of the MEP pathway. The cloverleaf fold and the active site of P. falciparum LytB corresponds to those of the Aquifex aeolicus and Escherichia coli enzymes. Its distinct electron donor [2Fe-2S] ferredoxin was modeled to its binding site by docking calculations. The presented structural data provide a platform for a rational search of anti-malarian drugs.

PubMed: 24188825
DOI: 10.1016/j.febslet.2013.10.029

実験手法

X-RAY DIFFRACTION (2.198 Å)