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4N64

Crystal structure of hemagglutinin from an H7N9 influenza virus in complex with a biantennary glycan receptor

4N64 の概要
エントリーDOI10.2210/pdb4n64/pdb
関連するPDBエントリー4N5J 4N5K 4N60 4N61 4N62 4N63
分子名称Hemagglutinin HA1, Hemagglutinin HA2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
機能のキーワードviral envelope protein, hemagglutinin, viral fusion protein, viral protein
由来する生物種Influenza A virus
詳細
タンパク質・核酸の鎖数4
化学式量合計114365.56
構造登録者
Xu, R.,Wilson, I.A. (登録日: 2013-10-11, 公開日: 2013-12-18, 最終更新日: 2024-11-27)
主引用文献Xu, R.,de Vries, R.P.,Zhu, X.,Nycholat, C.M.,McBride, R.,Yu, W.,Paulson, J.C.,Wilson, I.A.
Preferential recognition of avian-like receptors in human influenza A H7N9 viruses.
Science, 342:1230-1235, 2013
Cited by
PubMed Abstract: The 2013 outbreak of avian-origin H7N9 influenza in eastern China has raised concerns about its ability to transmit in the human population. The hemagglutinin glycoprotein of most human H7N9 viruses carries Leu(226), a residue linked to adaptation of H2N2 and H3N2 pandemic viruses to human receptors. However, glycan array analysis of the H7 hemagglutinin reveals negligible binding to humanlike α2-6-linked receptors and strong preference for a subset of avian-like α2-3-linked glycans recognized by all avian H7 viruses. Crystal structures of H7N9 hemagglutinin and six hemagglutinin-glycan complexes have elucidated the structural basis for preferential recognition of avian-like receptors. These findings suggest that the current human H7N9 viruses are poorly adapted for efficient human-to-human transmission.
PubMed: 24311689
DOI: 10.1126/science.1243761
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.7014 Å)
構造検証レポート
Validation report summary of 4n64
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-02-05に公開中

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