4N5B

Crystal structure of the Nipah virus phosphoprotein tetramerization domain

Summary for 4N5B

Entry DOI	10.2210/pdb4n5b/pdb
Descriptor	Phosphoprotein, IMIDAZOLE (3 entities in total)
Functional Keywords	viral polymerase co-factor, nucleoprotein chaperone, interferon inhibitor, viral protein
Biological source	Nipah virus
Total number of polymer chains	8
Total formula weight	102429.48
Authors	Bruhn, J.F.,Barnett, K.,Bibby, J.,Thomas, J.,Keegan, R.,Rigden, D.,Bornholdt, Z.A.,Saphire, E.O. (deposition date: 2013-10-09, release date: 2013-11-27, Last modification date: 2023-09-20)
Primary citation	Bruhn, J.F.,Barnett, K.C.,Bibby, J.,Thomas, J.M.,Keegan, R.M.,Rigden, D.J.,Bornholdt, Z.A.,Saphire, E.O. Crystal structure of the nipah virus phosphoprotein tetramerization domain. J.Virol., 88:758-762, 2014 Cited by PubMed Abstract: The Nipah virus phosphoprotein (P) is multimeric and tethers the viral polymerase to the nucleocapsid. We present the crystal structure of the multimerization domain of Nipah virus P: a long, parallel, tetrameric, coiled coil with a small, α-helical cap structure. Across the paramyxoviruses, these domains share little sequence identity yet are similar in length and structural organization, suggesting a common requirement for scaffolding or spatial organization of the functions of P in the virus life cycle. PubMed: 24155387 DOI: 10.1128/JVI.02294-13 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation