4N5B

Crystal structure of the Nipah virus phosphoprotein tetramerization domain

4N5B の概要

• エントリーDOI: 10.2210/pdb4n5b/pdb
• 分子名称: Phosphoprotein, IMIDAZOLE (3 entities in total)
• 機能のキーワード: viral polymerase co-factor, nucleoprotein chaperone, interferon inhibitor, viral protein
• 由来する生物種: Nipah virus
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 102429.48

構造登録者

Bruhn, J.F.,Barnett, K.,Bibby, J.,Thomas, J.,Keegan, R.,Rigden, D.,Bornholdt, Z.A.,Saphire, E.O. (登録日: 2013-10-09, 公開日: 2013-11-27, 最終更新日: 2023-09-20)

主引用文献

Bruhn, J.F.,Barnett, K.C.,Bibby, J.,Thomas, J.M.,Keegan, R.M.,Rigden, D.J.,Bornholdt, Z.A.,Saphire, E.O.
Crystal structure of the nipah virus phosphoprotein tetramerization domain.
J.Virol., 88:758-762, 2014

PubMed Abstract: The Nipah virus phosphoprotein (P) is multimeric and tethers the viral polymerase to the nucleocapsid. We present the crystal structure of the multimerization domain of Nipah virus P: a long, parallel, tetrameric, coiled coil with a small, α-helical cap structure. Across the paramyxoviruses, these domains share little sequence identity yet are similar in length and structural organization, suggesting a common requirement for scaffolding or spatial organization of the functions of P in the virus life cycle.

PubMed: 24155387
DOI: 10.1128/JVI.02294-13

実験手法

X-RAY DIFFRACTION (2.2 Å)