4MY2

Crystal Structure of Norrin in fusion with Maltose Binding Protein

4MY2 の概要

• エントリーDOI: 10.2210/pdb4my2/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose-binding periplasmic protein, Norrin fusion protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
• 機能のキーワード: cystine-knot growth factor, wnt signaling, cysteine-rich protein, angiogenesis, eye development, wnt/beta-catenin signaling, frizzled 4 receptor, lrp5/6, extracellular, fusion protein, signaling protein
• 由来する生物種: Escherichia coli O157:H7; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53177.46

構造登録者

Ke, J.,Jurecky, C.,Chen, C.,Gu, X.,Parker, N.,Williams, B.O.,Melcher, K.,Xu, H.E. (登録日: 2013-09-27, 公開日: 2013-11-13, 最終更新日: 2023-09-20)

• 主引用文献: Ke, J.,Harikumar, K.G.,Erice, C.,Chen, C.,Gu, X.,Wang, L.,Parker, N.,Cheng, Z.,Xu, W.,Williams, B.O.,Melcher, K.,Miller, L.J.,Xu, H.E.; Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.; Genes Dev., 27:2305-2319, 2013; PubMed: 24186977; DOI: 10.1101/gad.228544.113

実験手法

X-RAY DIFFRACTION (2.4 Å)