4MX9

CDPK1 from Neospora caninum in complex with inhibitor UW1294

Summary for 4MX9

• Entry DOI: 10.2210/pdb4mx9/pdb
• Related: 4M97
• Descriptor: Calmodulin-like domain protein kinase isoenzyme gamma, related, 3-(6-ethoxynaphthalen-2-yl)-1-[(1-methylpiperidin-4-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: serine/threonine protein kinase, transferase, calcium-binding, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Neospora caninum
• Total number of polymer chains: 1
• Total formula weight: 55500.21

Authors

Merritt, E.A. (deposition date: 2013-09-26, release date: 2013-10-09, Last modification date: 2023-09-20)

• Primary citation: Ojo, K.K.,Reid, M.C.,Kallur Siddaramaiah, L.,Muller, J.,Winzer, P.,Zhang, Z.,Keyloun, K.R.,Vidadala, R.S.,Merritt, E.A.,Hol, W.G.,Maly, D.J.,Fan, E.,Van Voorhis, W.C.,Hemphill, A.; Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.; Plos One, 9:e92929-e92929, 2014; PubMed: 24681759; DOI: 10.1371/journal.pone.0092929

Experimental method

X-RAY DIFFRACTION (3.1 Å)