4MX9

CDPK1 from Neospora caninum in complex with inhibitor UW1294

4MX9 の概要

• エントリーDOI: 10.2210/pdb4mx9/pdb
• 関連するPDBエントリー: 4M97
• 分子名称: Calmodulin-like domain protein kinase isoenzyme gamma, related, 3-(6-ethoxynaphthalen-2-yl)-1-[(1-methylpiperidin-4-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: serine/threonine protein kinase, transferase, calcium-binding, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Neospora caninum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55500.21

構造登録者

Merritt, E.A. (登録日: 2013-09-26, 公開日: 2013-10-09, 最終更新日: 2023-09-20)

• 主引用文献: Ojo, K.K.,Reid, M.C.,Kallur Siddaramaiah, L.,Muller, J.,Winzer, P.,Zhang, Z.,Keyloun, K.R.,Vidadala, R.S.,Merritt, E.A.,Hol, W.G.,Maly, D.J.,Fan, E.,Van Voorhis, W.C.,Hemphill, A.; Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.; Plos One, 9:e92929-e92929, 2014; PubMed: 24681759; DOI: 10.1371/journal.pone.0092929

実験手法

X-RAY DIFFRACTION (3.1 Å)