4MWO

Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor CPB-T

4MWO の概要

• エントリーDOI: 10.2210/pdb4mwo/pdb
• 分子名称: 5'(3')-deoxyribonucleotidase, mitochondrial, 1-{3,5-O-[(4-carboxyphenyl)(phosphono)methylidene]-2-deoxy-beta-D-threo-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: 5'-nucleotidase, protein conformation, dephosphorylation, phosphorylation, had-like, mitochondia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion: Q9NPB1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24072.17

構造登録者

Pachl, P.,Rezacova, P.,Brynda, J. (登録日: 2013-09-25, 公開日: 2014-09-10, 最終更新日: 2023-09-20)

• 主引用文献: Simak, O.,Pachl, P.,Fabry, M.,Budesinsky, M.,Jandusik, T.,Hnizda, A.,Sklenickova, R.,Petrova, M.,Veverka, V.,Rezacova, P.,Brynda, J.,Rosenberg, I.; Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases.; Org.Biomol.Chem., 12:7971-7982, 2014; PubMed: 25178098; DOI: 10.1039/c4ob01332h

実験手法

X-RAY DIFFRACTION (1.67 Å)