4MU7
Crystal structure of cIAP1 BIR3 bound to T3450325
Summary for 4MU7
Entry DOI | 10.2210/pdb4mu7/pdb |
Related | 4MTI |
Descriptor | Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,10aS)-2-[(2S)-2-cyclohexyl-2-{[(2S)-2-(methylamino)butanoyl]amino}acetyl]-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indole-3-carboxamide, ... (4 entities in total) |
Functional Keywords | ring-type zinc finger, ligase, apoptosis inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13490 |
Total number of polymer chains | 2 |
Total formula weight | 27895.98 |
Authors | Snell, G.P.,Dougan, D.R. (deposition date: 2013-09-20, release date: 2013-12-11, Last modification date: 2024-02-28) |
Primary citation | Shiokawa, Z.,Hashimoto, K.,Saito, B.,Oguro, Y.,Sumi, H.,Yabuki, M.,Yoshimatsu, M.,Kosugi, Y.,Debori, Y.,Morishita, N.,Dougan, D.R.,Snell, G.P.,Yoshida, S.,Ishikawa, T. Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells. Bioorg.Med.Chem., 21:7938-7954, 2013 Cited by PubMed: 24169315DOI: 10.1016/j.bmc.2013.09.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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