4MQY

Crystal Structure of the Escherichia coli LpxC/LPC-138 complex

4MQY の概要

• エントリーDOI: 10.2210/pdb4mqy/pdb
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-2-methyl-1-nitroso-1-oxobutan-2-yl]benzamide, ... (7 entities in total)
• 機能のキーワード: lpxc, antibiotic, acyl udp-glcnac, hydroxamate, lpc-138, baab sandwich, lipid a biosynthesis, lipid a synthesis, deacetylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35269.38

構造登録者

Lee, C.-J.,Najeeb, J.,Zhou, P. (登録日: 2013-09-17, 公開日: 2013-10-23, 最終更新日: 2024-02-28)

• 主引用文献: Lee, C.J.,Liang, X.,Gopalaswamy, R.,Najeeb, J.,Ark, E.D.,Toone, E.J.,Zhou, P.; Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.; Acs Chem.Biol., 9:237-246, 2014; PubMed: 24117400; DOI: 10.1021/cb400067g

実験手法

X-RAY DIFFRACTION (2.005 Å)