4MJ6

Crystal Structure of HLA-A*1101 in complex with H7-22, an influenza A(H7N9) virus epitope

4MJ6 の概要

• エントリーDOI: 10.2210/pdb4mj6/pdb
• 関連するPDBエントリー: 4MJ5
• 分子名称: HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, Nucleoprotein, ... (4 entities in total)
• 機能のキーワード: mhc, t cell responses, immune system-peptide complex, immune system/peptide
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P13746; Secreted : P61769; Host nucleus : R4X2K3
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44972.09

構造登録者

Liu, J.,Tan, S.,Zhao, M.,Qi, J.,Gao, G.F. (登録日: 2013-09-03, 公開日: 2014-10-08, 最終更新日: 2022-08-24)

主引用文献

Liu, W.J.,Tan, S.,Zhao, M.,Quan, C.,Bi, Y.,Wu, Y.,Zhang, S.,Zhang, H.,Xiao, H.,Qi, J.,Yan, J.,Liu, W.,Yu, H.,Shu, Y.,Wu, G.,Gao, G.F.
Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.
J.Infect.Dis., 214:1937-1946, 2016

PubMed Abstract:  The emergence of infections by the novel avian influenza A(H7N9) virus has posed a threat to human health. Cross-immunity between A(H7N9) and other heterosubtypic influenza viruses affected by antigenicity-dependent substitutions needs to be investigated.

PubMed: 27738054
DOI: 10.1093/infdis/jiw471

実験手法

X-RAY DIFFRACTION (2.57 Å)