4MIK

Crystal Structure of hPNMT in Complex with bisubstrate inhibitor (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(((2-(((7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)amino)ethyl)thio)methyl)tetrahydrofuran-3,4-diol

Summary for 4MIK

• Entry DOI: 10.2210/pdb4mik/pdb
• Related: 1HNN 2G72
• Descriptor: Phenylethanolamine N-methyltransferase, 9-{5-S-[2-({[(3S)-7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl}amino)ethyl]-5-thio-alpha-L-lyxofuranosyl}-9H-purin-6-amine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• Functional Keywords: methyltransferase, adrenaline synthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64969.37

Authors

Bart, A.G.,Scott, E.E. (deposition date: 2013-08-31, release date: 2014-09-10, Last modification date: 2018-01-24)

• Primary citation: Bart, A.G.,Scott, E.E.; To be published; To be Published,

Experimental method

X-RAY DIFFRACTION (1.9506 Å)