4MIK

Crystal Structure of hPNMT in Complex with bisubstrate inhibitor (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(((2-(((7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)amino)ethyl)thio)methyl)tetrahydrofuran-3,4-diol

4MIK の概要

• エントリーDOI: 10.2210/pdb4mik/pdb
• 関連するPDBエントリー: 1HNN 2G72
• 分子名称: Phenylethanolamine N-methyltransferase, 9-{5-S-[2-({[(3S)-7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl}amino)ethyl]-5-thio-alpha-L-lyxofuranosyl}-9H-purin-6-amine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: methyltransferase, adrenaline synthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64969.37

構造登録者

Bart, A.G.,Scott, E.E. (登録日: 2013-08-31, 公開日: 2014-09-10, 最終更新日: 2018-01-24)

• 主引用文献: Bart, A.G.,Scott, E.E.; To be published; To be Published,

実験手法

X-RAY DIFFRACTION (1.9506 Å)