4MI0

Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2)

Summary for 4MI0

Entry DOI	10.2210/pdb4mi0/pdb
Descriptor	Histone-lysine N-methyltransferase EZH2, ZINC ION, UNKNOWN ATOM OR ION, ... (4 entities in total)
Functional Keywords	ezh2, gene regulation, chromatin modification, histone methyltransferase, transcription, gene silencing, polycomb repressive complex 2, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q15910
Total number of polymer chains	1
Total formula weight	27098.87
Authors	Dong, A.,Zeng, H.,He, H.,Wernimont, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2013-08-30, release date: 2013-09-25, Last modification date: 2024-02-28)
Primary citation	Wu, H.,Zeng, H.,Dong, A.,Li, F.,He, H.,Senisterra, G.,Seitova, A.,Duan, S.,Brown, P.J.,Vedadi, M.,Arrowsmith, C.H.,Schapira, M. Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8:e83737-e83737, 2013 Cited by PubMed: 24367611 DOI: 10.1371/journal.pone.0083737 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation