4MI0

Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2)

4MI0 の概要

• エントリーDOI: 10.2210/pdb4mi0/pdb
• 分子名称: Histone-lysine N-methyltransferase EZH2, ZINC ION, UNKNOWN ATOM OR ION, ... (4 entities in total)
• 機能のキーワード: ezh2, gene regulation, chromatin modification, histone methyltransferase, transcription, gene silencing, polycomb repressive complex 2, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q15910
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27098.87

構造登録者

Dong, A.,Zeng, H.,He, H.,Wernimont, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Wu, H.,Structural Genomics Consortium (SGC) (登録日: 2013-08-30, 公開日: 2013-09-25, 最終更新日: 2024-02-28)

• 主引用文献: Wu, H.,Zeng, H.,Dong, A.,Li, F.,He, H.,Senisterra, G.,Seitova, A.,Duan, S.,Brown, P.J.,Vedadi, M.,Arrowsmith, C.H.,Schapira, M.; Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.; Plos One, 8:e83737-e83737, 2013; PubMed: 24367611; DOI: 10.1371/journal.pone.0083737

実験手法

X-RAY DIFFRACTION (2 Å)