4MGP

Structure of racemic Ala-(8,13,18) Magainin 2

4MGP の概要

• エントリーDOI: 10.2210/pdb4mgp/pdb
• 関連するPDBエントリー: 1DUM 2MAG
• 分子名称: Magainin 2 Derivative (2 entities in total)
• 機能のキーワード: phenylalanine zipper, antimicrobial protein
• 由来する生物種: Xenopus laevis (clawed frog,common platanna,platanna)
• 細胞内の位置: Secreted: P11006
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2483.99

構造登録者

Hayouka, Z.,Mortenson, D.E.,Kreitler, D.F.,Weisblum, B.,Gellman, S.H.,Forest, K.T. (登録日: 2013-08-28, 公開日: 2013-10-16, 最終更新日: 2023-09-20)

主引用文献

Hayouka, Z.,Mortenson, D.E.,Kreitler, D.F.,Weisblum, B.,Forest, K.T.,Gellman, S.H.
Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-ray Crystal Structure of a Magainin 2 Analogue.
J.Am.Chem.Soc., 135:15738-15741, 2013

PubMed Abstract: High-resolution structure elucidation has been challenging for the large group of host-defense peptides that form helices on or within membranes but do not manifest a strong folding propensity in aqueous solution. Here we report the crystal structure of an analogue of the widely studied host-defense peptide magainin 2. Magainin 2 (S8A, G13A, G18A) is a designed variant that displays enhanced antibacterial activity relative to the natural peptide. The crystal structure of magainin 2 (S8A, G13A, G18A), obtained for the racemic form, features a dimerization mode that has previously been proposed to play a role in the antibacterial activity of magainin 2 and related peptides.

PubMed: 24102563
DOI: 10.1021/ja409082w

実験手法

X-RAY DIFFRACTION (1.75 Å)