4MEQ

Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand

4MEQ の概要

• エントリーDOI: 10.2210/pdb4meq/pdb
• 関連するPDBエントリー: 4MEN 4MEO 4MEP
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 5-methyl-7-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, ... (4 entities in total)
• 機能のキーワード: brd4, cap, hunk1, mcap, mitotic chromosome associated protein, brd, small molecule inhibitor, structural genomics consortium, sgc, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15386.70

構造登録者

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,Vidler, L.R.,Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Hoelder, S.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2013-08-27, 公開日: 2013-09-25, 最終更新日: 2023-09-20)

• 主引用文献: Vidler, L.R.,Filippakopoulos, P.,Fedorov, O.,Picaud, S.,Martin, S.,Tomsett, M.,Woodward, H.,Brown, N.,Knapp, S.,Hoelder, S.; Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening.; J.Med.Chem., 56:8073-8088, 2013; PubMed: 24090311; DOI: 10.1021/jm4011302

実験手法

X-RAY DIFFRACTION (1.77 Å)