4MC5

Crystal structure of a subtype H18 hemagglutinin homologue from A/flat-faced bat/Peru/033/2010 (H18N11)

4MC5 の概要

• エントリーDOI: 10.2210/pdb4mc5/pdb
• 関連するPDBエントリー: 4K3X 4MC4 4MC6
• 分子名称: Hemagglutinin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: bat, influenza, viral protein
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 179795.50

構造登録者

Yang, H.,Carney, P.J.,Chang, J.C.,Guo, Z.,Stevens, J. (登録日: 2013-08-21, 公開日: 2013-10-23, 最終更新日: 2024-10-30)

主引用文献

Tong, S.,Zhu, X.,Li, Y.,Shi, M.,Zhang, J.,Bourgeois, M.,Yang, H.,Chen, X.,Recuenco, S.,Gomez, J.,Chen, L.M.,Johnson, A.,Tao, Y.,Dreyfus, C.,Yu, W.,McBride, R.,Carney, P.J.,Gilbert, A.T.,Chang, J.,Guo, Z.,Davis, C.T.,Paulson, J.C.,Stevens, J.,Rupprecht, C.E.,Holmes, E.C.,Wilson, I.A.,Donis, R.O.
New world bats harbor diverse influenza a viruses.
Plos Pathog., 9:e1003657-e1003657, 2013

PubMed Abstract: Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggests that other New World species may similarly carry divergent influenza viruses. Using consensus degenerate RT-PCR, we identified a novel influenza A virus, designated as H18N11, in a flat-faced fruit bat (Artibeus planirostris) from Peru. Serologic studies with the recombinant H18 protein indicated that several Peruvian bat species were infected by this virus. Phylogenetic analyses demonstrate that, in some gene segments, New World bats harbor more influenza virus genetic diversity than all other mammalian and avian species combined, indicative of a long-standing host-virus association. Structural and functional analyses of the hemagglutinin and neuraminidase indicate that sialic acid is not a ligand for virus attachment nor a substrate for release, suggesting a unique mode of influenza A virus attachment and activation of membrane fusion for entry into host cells. Taken together, these findings indicate that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.

PubMed: 24130481
DOI: 10.1371/journal.ppat.1003657

実験手法

X-RAY DIFFRACTION (2.238 Å)