4MBS
Crystal Structure of the CCR5 Chemokine Receptor
Summary for 4MBS
Entry DOI | 10.2210/pdb4mbs/pdb |
Descriptor | Chimera protein of C-C chemokine receptor type 5 and Rubredoxin, 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | human ccr5 chemokine receptor, anti-hiv agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, seven transmembrane helices, g protein-coupled receptor, membrane, signaling protein |
Biological source | Homo sapiens More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P51681 |
Total number of polymer chains | 2 |
Total formula weight | 99756.11 |
Authors | Tan, Q.,Zhu, Y.,Han, G.W.,Li, J.,Fenalti, G.,Liu, H.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR),Zhao, Q.,Wu, B. (deposition date: 2013-08-19, release date: 2013-09-11, Last modification date: 2023-09-20) |
Primary citation | Tan, Q.,Zhu, Y.,Li, J.,Chen, Z.,Han, G.W.,Kufareva, I.,Li, T.,Ma, L.,Fenalti, G.,Li, J.,Zhang, W.,Xie, X.,Yang, H.,Jiang, H.,Cherezov, V.,Liu, H.,Stevens, R.C.,Zhao, Q.,Wu, B. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science, 341:1387-1390, 2013 Cited by PubMed: 24030490DOI: 10.1126/science.1241475 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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