4MBP

MALTODEXTRIN BINDING PROTEIN WITH BOUND MALTETROSE

4MBP の概要

• エントリーDOI: 10.2210/pdb4mbp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900010
• 分子名称: MALTODEXTRIN BINDING PROTEIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
• 機能のキーワード: periplasmic binding protein, transport, sugar transport
• 由来する生物種: Escherichia coli
• 細胞内の位置: Periplasm: P02928
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41419.73

構造登録者

Spurlino, J.C.,Quiocho, F.A. (登録日: 1997-08-17, 公開日: 1998-02-25, 最終更新日: 2024-05-22)

主引用文献

Quiocho, F.A.,Spurlino, J.C.,Rodseth, L.E.
Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5:997-1015, 1997

PubMed Abstract: Active-transport processes perform a vital function in the life of a cell, maintaining cell homeostasis and allowing access of nutrients. Maltodextrin/maltose-binding protein (MBP; M(r) = 40k) is a receptor protein which serves as an initial high-affinity binding component of the active-transport system of maltooligosaccharides in bacteria. MBP also participates in chemotaxis towards maltooligosaccharides. The interaction between MBP and specific cytoplasmic membrane proteins initiates either active transport or chemotaxis. In order to gain new understanding of the function of MBP, especially its versatility in binding different linear and cyclic oligosaccharides with similar affinities, we have undertaken high-resolution X-ray analysis of three oligosaccharide-bound structures.

PubMed: 9309217
DOI: 10.1016/S0969-2126(97)00253-0

実験手法

X-RAY DIFFRACTION (1.7 Å)