4MBC
Structure of Streptococcus pneumonia ParE in complex with AZ13053807
Summary for 4MBC
Entry DOI | 10.2210/pdb4mbc/pdb |
Related | 4EM7 4EMV 4MB9 |
Descriptor | DNA topoisomerase IV, B subunit, 1-{5-[2-(morpholin-4-yl)ethoxy]-6-(pyridin-3-yl)[1,3]thiazolo[5,4-b]pyridin-2-yl}-3-prop-2-en-1-ylurea (3 entities in total) |
Functional Keywords | atp binding, structure-based drug design, antimicrobial, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Streptococcus pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 25041.24 |
Authors | Ogg, D.,Tucker, J. (deposition date: 2013-08-19, release date: 2013-10-16, Last modification date: 2024-02-28) |
Primary citation | Kale, M.G.,Raichurkar, A.,Hameed, S.P.,Waterson, D.,McKinney, D.,Manjunatha, M.R.,Kranthi, U.,Koushik, K.,Jena, L.K.,Shinde, V.,Rudrapatna, S.,Barde, S.,Humnabadkar, V.,Madhavapeddi, P.,Basavarajappa, H.,Ghosh, A.,Ramya, V.,Guptha, S.,Sharma, S.,Vachaspati, P.,Kumar, K.N.,Giridhar, J.,Reddy, J.,Panduga, V.,Ganguly, S.,Ahuja, V.,Gaonkar, S.,Kumar, C.N.,Ogg, D.,Tucker, J.A.,Boriack-Sjodin, P.A.,de Sousa, S.M.,Sambandamurthy, V.K.,Ghorpade, S.R. Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B. J.Med.Chem., 56:8834-8848, 2013 Cited by PubMed: 24088190DOI: 10.1021/jm401268f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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