4M7U
Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)
Summary for 4M7U
| Entry DOI | 10.2210/pdb4m7u/pdb |
| Related | 4M7V |
| Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
| Functional Keywords | oxidoreductase, reduction of dihydrofolate to tetrahydrofolate |
| Biological source | Enterococcus faecalis |
| Total number of polymer chains | 1 |
| Total formula weight | 20789.20 |
| Authors | Bourne, C.R. (deposition date: 2013-08-12, release date: 2014-03-05, Last modification date: 2023-09-20) |
| Primary citation | Bourne, C.R.,Wakeham, N.,Webb, N.,Nammalwar, B.,Bunce, R.A.,Berlin, K.D.,Barrow, W.W. The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking. Biochemistry, 53:1228-1238, 2014 Cited by PubMed: 24495113DOI: 10.1021/bi401104t PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1014 Å) |
Structure validation
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