4M7I

Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867) at 2.34A Resolution

Summary for 4M7I

• Entry DOI: 10.2210/pdb4m7i/pdb
• Related: 3QD2 4G31 4G34
• Descriptor: Eukaryotic translation initiation factor 2-alpha kinase 3, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone (3 entities in total)
• Functional Keywords: deletion mutant, catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein: Q9NZJ5
• Total number of polymer chains: 1
• Total formula weight: 35211.65

Authors

Gampe, R.T.,Axten, J.M. (deposition date: 2013-08-12, release date: 2014-09-03, Last modification date: 2023-09-20)

• Primary citation: Axten, J.M.,Romeril, S.P.,Shu, A.,Ralph, J.,Medina, J.R.,Feng, Y.,Li, W.H.H.,Grant, S.W.,Heerding, D.A.,Minthorn, E.,Mencken, T.,Gaul, N.,Goetz, A.,Stanley, T.,Hassell, A.M.,Gampe, R.T.,Atkins, C.,Kumar, R.; Discovery of 5-{4-fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2656157), a Potent and Selective PERK Inhibitor Selected for Preclinical Development; To be Published,

Experimental method

X-RAY DIFFRACTION (2.34 Å)