4M40

Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998

4M40 の概要

• エントリーDOI: 10.2210/pdb4m40/pdb
• 関連するPDBエントリー: 4M44
• 分子名称: Hemagglutinin HA1, Hemagglutinin HA2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: receptor binding, fusion, sialic acid, viral protein
• 由来する生物種: Influenza B virus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 177732.17

構造登録者

Ni, F.,Kondrashkina, E.,Wang, Q. (登録日: 2013-08-06, 公開日: 2013-09-25, 最終更新日: 2024-10-30)

主引用文献

Ni, F.,Kondrashkina, E.,Wang, Q.
Structural basis for the divergent evolution of influenza B virus hemagglutinin.
Virology, 446:112-122, 2013

PubMed Abstract: Influenza A and B viruses are responsible for the severe morbidity and mortality worldwide in annual influenza epidemics. Currently circulating influenza B virus belongs to the B/Victoria or B/Yamagata lineage that was diverged from each other about 30-40 years ago. However, a mechanistic understanding of their divergent evolution is still lacking. Here we report the crystal structures of influenza B/Yamanashi/166/1998 hemagglutinin (HA) belonging to B/Yamagata lineage and its complex with the avian-like receptor analogue. Comparison of these structures with those of undiverged and diverged influenza B virus HAs, in conjunction with sequence analysis, reveals the molecular basis for the divergent evolution of influenza B virus HAs. Furthermore, HAs of diverged influenza B virus strains display much stronger molecular interactions with terminal sialic acid of bound receptors, which may allow for a different tissue tropism for current influenza B viruses, for which further investigation is required.

PubMed: 24074573
DOI: 10.1016/j.virol.2013.07.035

実験手法

X-RAY DIFFRACTION (3.54 Å)