4M2Y

Structure of human DNA polymerase beta complexed with 8-BrG as the template base in a 1-nucleotide gapped DNA

Summary for 4M2Y

• Entry DOI: 10.2210/pdb4m2y/pdb
• Related: 1BPX 3ISB 4M47
• Descriptor: DNA polymerase beta, template DNA strand, up-primer, ... (6 entities in total)
• Functional Keywords: promutagenic 8-halogenated g insertion, polymerase -dna complex, base excision repair, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 46671.39

Authors

Koag, M.C.,Min, K.,Monzingo, A.F.,Lee, S. (deposition date: 2013-08-05, release date: 2014-01-22, Last modification date: 2023-09-20)

• Primary citation: Koag, M.C.,Min, K.,Lee, S.; Structural basis for promutagenicity of 8-halogenated Guanine.; J.Biol.Chem., 289:6289-6298, 2014; PubMed: 24425881; DOI: 10.1074/jbc.M113.537803

Experimental method

X-RAY DIFFRACTION (2.27 Å)