4LY1

Structure of Human HDAC2 in complex with inhibitor 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide

Summary for 4LY1

Entry DOI	10.2210/pdb4ly1/pdb
Related	4LXZ
Descriptor	Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (8 entities in total)
Functional Keywords	deacetylase, histone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q92769
Total number of polymer chains	3
Total formula weight	130302.50
Authors	Fong, R.,Lupardus, P.J. (deposition date: 2013-07-30, release date: 2013-08-21, Last modification date: 2023-09-20)
Primary citation	Lauffer, B.E.,Mintzer, R.,Fong, R.,Mukund, S.,Tam, C.,Zilberleyb, I.,Flicke, B.,Ritscher, A.,Fedorowicz, G.,Vallero, R.,Ortwine, D.F.,Gunzner, J.,Modrusan, Z.,Neumann, L.,Koth, C.M.,Lupardus, P.J.,Kaminker, J.S.,Heise, C.E.,Steiner, P. Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability. J.Biol.Chem., 288:26926-26943, 2013 Cited by PubMed: 23897821 DOI: 10.1074/jbc.M113.490706 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation