4LVQ

Crystal structure of the M. tuberculosis phosphate binding protein PstS3

4LVQ の概要

• エントリーDOI: 10.2210/pdb4lvq/pdb
• 分子名称: Phosphate-binding protein PstS 3, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: phosphate binding protein, extracellular, transport protein
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77809.43

構造登録者

Ferraris, D.M.,Rizzi, M. (登録日: 2013-07-26, 公開日: 2014-03-26, 最終更新日: 2024-11-27)

主引用文献

Ferraris, D.M.,Spallek, R.,Oehlmann, W.,Singh, M.,Rizzi, M.
Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3.
Proteins, 82:2268-2274, 2014

PubMed Abstract: Mycobacterium tuberculosis evades host immune responses by colonizing macrophages. Intraphagosomal M. tuberculosis is exposed to environmental stresses such as reactive oxygen and nitrogen intermediates as well as acid shock and inorganic phosphate (Pi) depletion. Experimental evidence suggests that expression levels of mycobacterial protein PstS3 (Rv0928) are significantly increased when M. tuberculosis bacilli are exposed to Pi starvation. Hence, PstS3 may be important for survival of Mtb in conditions where there is limited supply of Pi. We report here the structure of PstS3 from M. tuberculosis at 2.3-Å resolution. The protein presents a structure typical for ABC phosphate transfer receptors. Comparison with its cognate receptor PstS1 showed a different pattern distribution of surface charges in proximity to the Pi recognition site, suggesting complementary roles of the two proteins in Pi uptake.

PubMed: 24615888
DOI: 10.1002/prot.24548

実験手法

X-RAY DIFFRACTION (2.3 Å)