4LUW

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine

4LUW の概要

• エントリーDOI: 10.2210/pdb4luw/pdb
• 関連するPDBエントリー: 4LUX 4LWA 4LWB
• 分子名称: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
• 機能のキーワード: nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Cell membrane : P29473
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102055.78

構造登録者

Li, H.,Poulos, T.L. (登録日: 2013-07-25, 公開日: 2013-10-23, 最終更新日: 2024-10-16)

主引用文献

Holden, J.K.,Li, H.,Jing, Q.,Kang, S.,Richo, J.,Silverman, R.B.,Poulos, T.L.
Structural and biological studies on bacterial nitric oxide synthase inhibitors.
Proc.Natl.Acad.Sci.USA, 110:18127-18131, 2013

PubMed Abstract: Nitric oxide (NO) produced by bacterial NOS functions as a cytoprotective agent against oxidative stress in Staphylococcus aureus, Bacillus anthracis, and Bacillus subtilis. The screening of several NOS-selective inhibitors uncovered two inhibitors with potential antimicrobial properties. These two compounds impede the growth of B. subtilis under oxidative stress, and crystal structures show that each compound exhibits a unique binding mode. Both compounds serve as excellent leads for the future development of antimicrobials against bacterial NOS-containing bacteria.

PubMed: 24145412
DOI: 10.1073/pnas.1314080110

実験手法

X-RAY DIFFRACTION (2.25 Å)