4LSL

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ476), a non-nucleoside inhibitor

4LSL の概要

• エントリーDOI: 10.2210/pdb4lsl/pdb
• 関連するPDBエントリー: 1S9E 2ZD1 4H4M 4H4O 4KKO 4LSN 4MFB
• 分子名称: HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, (2E)-3-(3-{4-chloro-2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, ... (4 entities in total)
• 機能のキーワード: polymerase, transferase, hydrolase, rnaseh, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114438.55

構造登録者

Frey, K.M.,Anderson, K.S. (登録日: 2013-07-22, 公開日: 2013-12-25, 最終更新日: 2023-09-20)

• 主引用文献: Frey, K.M.,Gray, W.T.,Spasov, K.A.,Bollini, M.,Gallardo-Macias, R.,Jorgensen, W.L.,Anderson, K.S.; Structure-Based Evaluation of C5 Derivatives in the Catechol Diether Series Targeting HIV-1 Reverse Transcriptase.; Chem.Biol.Drug Des., 83:541-549, 2014; PubMed: 24289305; DOI: 10.1111/cbdd.12266

実験手法

X-RAY DIFFRACTION (2.69 Å)