4LRR

Ternary complex between E. coli thymidylate synthase, dUMP, and F9

Summary for 4LRR

Entry DOI	10.2210/pdb4lrr/pdb
Related	4LRP
Descriptor	Thymidylate synthase, SULFATE ION, 2-oxo-2H-naphtho[1,8-bc]furan-6-yl 4-nitrobenzoate, ... (5 entities in total)
Functional Keywords	thymidine monophosphate synthesis, n-terminal acetylated methionine, beta-mercaptoethanol modified cysteine, transferase
Biological source	Escherichia coli
Cellular location	Cytoplasm (By similarity): P0A886
Total number of polymer chains	1
Total formula weight	31999.74
Authors	Mangani, S.,Pozzi, C.,Ferrari, S.,Costi, M.P. (deposition date: 2013-07-20, release date: 2013-11-06, Last modification date: 2013-12-11)
Primary citation	Ferrari, S.,Calo, S.,Leone, R.,Luciani, R.,Costantino, L.,Sammak, S.,Di Pisa, F.,Pozzi, C.,Mangani, S.,Costi, M.P. 2'-Deoxyuridine 5'-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives. J.Med.Chem., 56:9356-9360, 2013 Cited by PubMed: 24147825 DOI: 10.1021/jm4014086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation