4LQM
EGFR L858R in complex with PD168393
Summary for 4LQM
Entry DOI | 10.2210/pdb4lqm/pdb |
Related | 2J5F 4LRM |
Descriptor | Epidermal growth factor receptor, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | egfr, kinase, pd168393, 34-jab, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38116.60 |
Authors | |
Primary citation | Yasuda, H.,Park, E.,Yun, C.H.,Sng, N.J.,Lucena-Araujo, A.R.,Yeo, W.L.,Huberman, M.S.,Cohen, D.W.,Nakayama, S.,Ishioka, K.,Yamaguchi, N.,Hanna, M.,Oxnard, G.R.,Lathan, C.S.,Moran, T.,Sequist, L.V.,Chaft, J.E.,Riely, G.J.,Arcila, M.E.,Soo, R.A.,Meyerson, M.,Eck, M.J.,Kobayashi, S.S.,Costa, D.B. Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer. Sci Transl Med, 5:216ra177-216ra177, 2013 Cited by PubMed: 24353160DOI: 10.1126/scitranslmed.3007205 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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