4LLW

Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A

Summary for 4LLW

Entry DOI	10.2210/pdb4llw/pdb
Related	4LLD 4LLM 4LLQ 4LLU 4LLY
Descriptor	mutated Pertuzumab Fab heavy chain, light chain Clambda, SULFATE ION, ... (4 entities in total)
Functional Keywords	fab, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	95476.10
Authors	Pustilnik, A.,Lewis, S.M.,Wu, X.,Sereno, A.,Huang, F.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Kuhlman, B.,Demarest, S.J.,Atwell, S. (deposition date: 2013-07-09, release date: 2014-01-29, Last modification date: 2019-06-26)
Primary citation	Lewis, S.M.,Wu, X.,Pustilnik, A.,Sereno, A.,Huang, F.,Rick, H.L.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Conner, E.M.,Atwell, S.,Kuhlman, B.,Demarest, S.J. Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32:191-198, 2014 Cited by PubMed: 24463572 DOI: 10.1038/nbt.2797 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation