4LLA

Crystal structure of D3D4 domain of the LILRB2 molecule

4LLA の概要

• エントリーDOI: 10.2210/pdb4lla/pdb
• 関連するPDBエントリー: 4LL9
• 分子名称: Leukocyte immunoglobulin-like receptor subfamily B member 2 (2 entities in total)
• 機能のキーワード: ig-like domain, immune-modulatory molecule, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q8N423
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 64566.69

構造登録者

Nam, G.,Shi, Y.,Ryu, M.,Wang, Q.,Song, H.,Liu, J.,Yan, J.,Qi, J.,Gao, G.F. (登録日: 2013-07-09, 公開日: 2013-09-11, 最終更新日: 2024-11-13)

主引用文献

Nam, G.,Shi, Y.,Ryu, M.,Wang, Q.,Song, H.,Liu, J.,Yan, J.,Qi, J.,Gao, G.F.
Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding
Protein Cell, 4:761-770, 2013

PubMed Abstract: Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with four Ig-like domains (D1D2D3D4). Thus far, the structural features of the D1D2 domains of LILR proteins are well defined, but no structures for the D3D4 domains have been reported. This is a very important field to be studied as it relates to the unknown functions of the D3D4 domains, as well as their relative orientation to the D1D2 domains on the cell surface. Here, we report the crystal structures of the D3D4 domains of both LILRB1 and LILRB2. The two Ig-like domains of both LILRB1-D3D4 and LILRB2-D3D4 are arranged at an acute angle (∼60°) to form a bent structure, resembling the structures of natural killer inhibitory receptors. Based on these two D3D4 domain structures and previously reported D1D2/HLA I complex structures, two alternative models of full-length (four Ig-like domains) LILR molecules bound to HLA I are proposed.

PubMed: 23955630
DOI: 10.1007/s13238-013-3908-x

実験手法

X-RAY DIFFRACTION (2.502 Å)