4LBD

LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961

4LBD の概要

• エントリーDOI: 10.2210/pdb4lbd/pdb
• 分子名称: RETINOIC ACID RECEPTOR GAMMA, 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID (3 entities in total)
• 機能のキーワード: nuclear receptor, retinoic acid receptor, all-trans retinoic acid, ligand-binding domain, complex, holo form, transcription regulation, ligand-dependent, active conformation, structural proteomics in europe, spine, structural genomics
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30592.51

構造登録者

Klaholz, B.P.,Renaud, J.-P.,Mitschler, A.,Moras, D.,Structural Proteomics in Europe (SPINE) (登録日: 1998-02-04, 公開日: 1999-03-02, 最終更新日: 2023-08-09)

• 主引用文献: Klaholz, B.P.,Renaud, J.P.,Mitschler, A.,Zusi, C.,Chambon, P.,Gronemeyer, H.,Moras, D.; Conformational adaptation of agonists to the human nuclear receptor RAR gamma.; Nat.Struct.Biol., 5:199-202, 1998; PubMed: 9501913; DOI: 10.1038/nsb0398-199

実験手法

X-RAY DIFFRACTION (2.5 Å)