4L7P

Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0395

Summary for 4L7P

Entry DOI	10.2210/pdb4l7p/pdb
Related	4L6Z 4L70 4L7L 4L7N 4L7O 4L7R 4L7U
Descriptor	Poly [ADP-ribose] polymerase 3, (2E)-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-1,4-dihydroquinazolin-2-yl)prop-2-enamide (3 entities in total)
Functional Keywords	diphtheria toxin like adp-ribose trasnferase, transferase, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9Y6F1
Total number of polymer chains	1
Total formula weight	40101.46
Authors	Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Ekblad, T.,Spjut, S.,Andersson, C.D.,Weigelt, J.,Linusson, A.,Elofsson, M.,Schuler, H. (deposition date: 2013-06-14, release date: 2014-02-19, Last modification date: 2023-09-20)
Primary citation	Lindgren, A.E.,Karlberg, T.,Ekblad, T.,Spjut, S.,Thorsell, A.G.,Andersson, C.D.,Nhan, T.T.,Hellsten, V.,Weigelt, J.,Linusson, A.,Schuler, H.,Elofsson, M. Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56:9556-9568, 2013 Cited by PubMed: 24188023 DOI: 10.1021/jm401394u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation