4L7J
Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)
4L7J の概要
エントリーDOI | 10.2210/pdb4l7j/pdb |
関連するPDBエントリー | 4L7G 4L7H 4LC7 |
分子名称 | Beta-secretase 1, 2-[(3aS,7aR)-2-amino-3a-(2,4-difluorophenyl)-3a,6,7,7a-tetrahydro[1,3]oxazolo[4,5-c]pyridin-5(4H)-yl]pyridine-3-carbonitrile, ACETATE ION, ... (4 entities in total) |
機能のキーワード | aspartic protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Membrane; Single-pass type I membrane protein: P56817 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 46017.59 |
構造登録者 | Huestis, M.P.,Liu, W.,Volgraf, M.,Purkey, H.E.,Wang, W.,Yu, C.,Wu, P.,Smith, D.,Vigers, G.,Dutcher, D.,Geck Do, M.K.,Hunt, K.W.,Siu, M. (登録日: 2013-06-13, 公開日: 2013-09-18, 最終更新日: 2023-09-20) |
主引用文献 | Huestis, M.P.,Liu, W.,Volgraf, M.,Purkey, H.,Yu, C.,Wang, W.,Smith, D.,Vigers, G.,Dutcher, D.,Hunt, K.W.,Siu, M. Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxycycloalkylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against β-Secretase-1 (BACE-1) Tetrahedron Lett., 2013 Cited by DOI: 10.1016/j.tetlet.2013.07.136主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.651 Å) |
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